Meyer Volker, Goerge Tobias, Luger Thomas A, Beissert Stefan
Department of Dermatology, University of Münster, Münster, Germany.
J Clin Aesthet Dermatol. 2011 Apr;4(4):45-6.
Palmoplantar hyperkeratotic psoriasis can be challenging to treat since micro-trauma induced by manual labor supports the development of new lesions via the isomorphic Koebner reaction. In this article, the authors report the successful treatment of severe palmoplantar hyperkeratotic psoriasis with etanercept and alitretinoin combination therapy. The results indicate that the new retinoid alitretinoin can be effectively used in combination with anti-tumor necrosis factor blocking agents for the treatment of psoriasis in individual cases.
掌跖角化过度型银屑病的治疗颇具挑战性，因为体力劳动引起的微创伤会通过同形反应（Koebner反应）促使新皮损的出现。在本文中，作者报告了用依那西普和阿利维A酸联合治疗重症掌跖角化过度型银屑病取得成功的案例。结果表明，新型维甲酸类药物阿利维A酸在个别病例中可有效地与抗肿瘤坏死因子阻断剂联合用于银屑病的治疗。
