Keme-Ebi Imananagha Kobina, Asindi Asindi Asindi
Department of Medicine, Neurologic Unit, Niger Delta University Teaching Hospital, Okolobiri, Nigeria;
Pan Afr Med J. 2008 Oct 30;1:4.
Locked-in syndrome is an extremely difficult neurologic condition to recognize, especially by the non-specialists. A case of locked-in syndrome in a 41-year old Niger Deltan Nigerian with relapsing remitting form of multiple sclerosis (MS) is presented, including a detailed literature review.
The patient was in a state of spastic quadriplegia, motionless and aphasic (mute), with the preservation of consciousness and the ability to open and blink the eyes and move them vertically. Two episodes of the disease, varying in duration, have been described. The diagnosis of MS was made from the history and the typical clinical presentation: history of relapsing and remitting signs and clinical evidence of multi-focal involvement of the central nervous system.
Patient died at the age of 45 years, from pulmonary complications. This article may enhance easy recognition and management of the syndrome by all clinicians.
闭锁综合征是一种极难识别的神经系统疾病，非专科医生尤其难以识别。本文报告了一例41岁患有复发缓解型多发性硬化症（MS）的尼日尔三角洲尼日利亚人患闭锁综合征的病例，并进行了详细的文献综述。
患者处于痉挛性四肢瘫痪状态，一动不动且失语（不能说话），但意识清醒，能够睁开和眨眼并垂直移动眼睛。描述了该疾病的两次发作，持续时间各不相同。根据病史和典型临床表现诊断为MS：有复发和缓解体征的病史以及中枢神经系统多灶性受累的临床证据。
患者45岁时死于肺部并发症。本文可能会提高所有临床医生对该综合征的识别和管理能力。
