Departments of Medicine and Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.
Sleep. 2011 May 1;34(5):661-9. doi: 10.1093/sleep/34.5.661.
We sought to evaluate the contribution of genetic and non-genetic factors on habitual sleep/wake patterns in a community-dwelling agrarian population using a physical activity monitoring device, the Actical.
Cross-sectional population-based study of healthy Old Order Amish enrolled in the Heredity and Phenotype Intervention (HAPI) Heart Study.
Lancaster County, PA, USA.
723 healthy adults (54% men) with a mean age of 43.3 ± 13.8 years (range: 20-80). 96% of the subjects were connected into one 5-generation pedigree.
N/A.
Participants wore Actical accelerometers 24 hours/day for 7 days to determine physical activity level, as well as habitual wake time, bedtime, and sleep duration. Participants completed the Horne-Östberg Morningness-Eveningness Questionnaire (MEQ), a modified Epworth Sleepiness Scale (ESS), and a lifestyle questionnaire. A sub-study of 164 participants kept sleep diaries.
Habitual wake time and bedtime determined by Actical were highly correlated with results from sleep diaries (r = 0.82 for wake time and 0.72 for bedtime, both P < 0.0001). After adjustment for age, sex, occupation, and season, higher activity level was associated with earlier wake time but not with bedtime, and correspondingly with shorter sleep duration. After adjustment for the aforementioned factors and the effects of a shared household, habitual wake time, MEQ score, and ESS score showed significant heritability (wake time h(2) = 0.20, MEQ h(2) = 0.21, and ESS h(2) = 0.17).
Objectively measured wake time, self-reported morningness-eveningness preference, and daytime sleepiness appear heritable and wake time may be associated with physical activity level.
我们试图使用活动监测设备 Actical 评估遗传和非遗传因素对农村社区居民习惯性睡眠/觉醒模式的影响。
健康的老派阿米什人参与的遗传与表型干预（HAPI）心脏研究的横断面基于人群的研究。
美国宾夕法尼亚州兰开斯特县。
723 名健康成年人（54%为男性），平均年龄为 43.3±13.8 岁（范围：20-80 岁）。96%的受试者被连接到一个 5 代血统中。
无。
参与者佩戴 Actical 活动监测器 24 小时/天，持续 7 天，以确定体力活动水平以及习惯性醒来时间、就寝时间和睡眠时间。参与者完成了 Horne-Östberg 清晨-傍晚型问卷（MEQ）、改良的 Epworth 嗜睡量表（ESS）和生活方式问卷。164 名参与者的亚研究组保留了睡眠日记。
Actical 确定的习惯性醒来时间和就寝时间与睡眠日记的结果高度相关（醒来时间 r=0.82，就寝时间 r=0.72，均 P<0.0001）。在校正年龄、性别、职业和季节后，较高的活动水平与较早的醒来时间相关，但与就寝时间无关，相应地与较短的睡眠时间相关。在校正上述因素以及共享家庭的影响后，习惯性醒来时间、MEQ 评分和 ESS 评分显示出显著的遗传性（醒来时间 h²=0.20，MEQ h²=0.21，ESS h²=0.17）。
客观测量的醒来时间、自我报告的早晨/傍晚偏好和白天嗜睡似乎具有遗传性，且醒来时间可能与体力活动水平相关。
