Department of Psychology, University of Memphis, Memphis, Tennessee, United States of America.
PLoS One. 2011 Apr 21;6(4):e19058. doi: 10.1371/journal.pone.0019058.
Manipulations of rearing conditions have been used to examine the effects of early experience on adult behavior with varying results. Evidence suggests that postnatal days (PND) 15-21 are a time of particular susceptibility to environmental influences on anxiety-like behavior in mice. To examine this, we subjected C57BL/6J and DBA/2J mice to an early handling-like procedure. Pups were separated from dams from PND 12-20 for 30 minutes daily or received standard care. On PND 21, pups were weaned and either individually- or group-housed. On PND 60, anxiety-like behavior was examined on the elevated zero-maze. Although individually-housed animals took longer to enter an open quadrant of the maze, they spent more time in the open than group-housed animals. Additionally, we observed a trend of reduced anxiety-like behavior in C57BL/6J, but not DBA/2J mice that underwent the handling-like procedure.
饲养条件的改变被用于研究早期经历对成年动物行为的影响，但结果不一。有证据表明，在出生后第 15-21 天，环境对小鼠类焦虑样行为的影响特别敏感。为了检验这一点，我们对 C57BL/6J 和 DBA/2J 小鼠进行了类似早期处理的实验。从出生后第 12-20 天起，每天将幼鼠与母鼠分开 30 分钟，或者进行标准护理。在出生后第 21 天，幼鼠断奶并单独或分组饲养。在出生后第 60 天，我们在高架十字迷宫上检查了焦虑样行为。虽然单独饲养的动物进入迷宫开放象限的时间更长，但它们在开放区域停留的时间比分组饲养的动物多。此外，我们观察到，接受类似早期处理的 C57BL/6J 小鼠表现出焦虑样行为减少的趋势，但 DBA/2J 小鼠没有这种趋势。
