α1-抗胰蛋白酶与肝细胞癌患者的生存率
Alpha 1-antitrypsin and survival in hepatocellular carcinoma.
作者信息
Tzonou A, Sparos L, Kalapothaki V, Zavitsanos X, Rebelakos A, Trichopoulos D
机构信息
Department of Hygiene and Epidemiology, University of Athens Medical School, Greece.
出版信息
Br J Cancer. 1990 Jan;61(1):72-3. doi: 10.1038/bjc.1990.16.
The association between serum levels of alpha 1-antitrypsin (alpha 1 AT) at the time of diagnosis and survival was studied in a group of 78 patients with confirmed hepatocellular carcinoma (HCC). All 78 patients were followed until the time of death, which occurred in all instances from HCC, with a median time of 6 months and a range of 1-117 months. Cox's proportional hazards model was utilised in the analysis controlling for sex, age, HBsAg status and logarithmically transformed values of alpha-fetoprotein (alpha-FP). Older patients and patients positive for HBsAg have suggestively higher fatality rates (0.05 less than P less than 0.10) whereas in these data sex and AFP levels were not important prognostic factors. Increased levels of serum at alpha 1AT at the time of diagnosis of HCC were statistically significantly (P less than 0.05) related with shorter survival, patients with higher serum alpha 1AT by 200 mg 100 ml-1 having an expected survival time shorter by about 25%.
在一组78例确诊为肝细胞癌（HCC）的患者中，研究了诊断时血清α1-抗胰蛋白酶（α1AT）水平与生存之间的关联。所有78例患者均被随访至死亡，所有患者均死于HCC，中位时间为6个月，范围为1 - 117个月。在分析中使用Cox比例风险模型，对性别、年龄、乙肝表面抗原（HBsAg）状态和甲胎蛋白（α-FP）的对数转换值进行控制。年龄较大的患者和HBsAg阳性的患者的死亡率较高（0.05＜P＜0.10），而在这些数据中，性别和甲胎蛋白水平不是重要的预后因素。HCC诊断时血清α1AT水平升高与较短的生存期具有统计学显著相关性（P＜0.05），血清α1AT水平每升高200mg/100ml，预期生存时间缩短约25%。
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