欧洲人群中肝癌患者和对照组的甲胎蛋白水平。

Alphafetoprotein levels of liver cancer patients and controls in a European population.

作者信息

Trichopoulos D, Sizaret P, Tabor E, Gerety R J, Martel N, Munoz N, Theodoropoulos G

出版信息

Cancer. 1980 Aug 15;46(4):736-40. doi: 10.1002/1097-0142(19800815)46:4<736::aid-cncr2820460417>3.0.co;2-x.

DOI:10.1002/1097-0142(19800815)46:4<736::aid-cncr2820460417>3.0.co;2-x

Abstract

Serum alphafetoprotein (AFP) levels were determined by radioimmunoassay for 80 patients with primary hepatocellular carcinoma (PHC), 40 with metastatic liver cancer (MLC), and 204 controls; all were Caucasians of Greek nationality. Among histologically confirmed PHC cases, 62% had more than 1000 International Units per millilitre (IU/ml) AFP. Only one case with MLC (3%) exceeded 1000 IU/ml AFP, but lower elevations were not uncommon (13%). Among controls, none exceeded 40 IU/ml. Hepatitis B surface antigen (HBsAg) was detected among 6% of 17 histologically confirmed PHC patients with AFP less than 100 IU/ml and 60% of 63 PHC patients with more than 100 IU/ml of AFP (p < 0.001). Control subjects positive for HBsAg had significantly higher AFP values compared to those negative for it (P < 0.01) and male controls had slightly higher AFP values than female controls.

摘要

采用放射免疫分析法测定了80例原发性肝细胞癌（PHC）患者、40例转移性肝癌（MLC）患者及204例对照者的血清甲胎蛋白（AFP）水平；所有研究对象均为希腊籍白种人。在组织学确诊的PHC病例中，62%的患者AFP水平超过每毫升1000国际单位（IU/ml）。仅有1例MLC患者（3%）的AFP水平超过1000 IU/ml，但较低程度的升高并不罕见（13%）。在对照者中，无人超过40 IU/ml。在17例组织学确诊且AFP低于100 IU/ml的PHC患者中，6%检测出乙肝表面抗原（HBsAg）；在63例AFP超过100 IU/ml的PHC患者中，60%检测出HBsAg（p<0.001）。HBsAg呈阳性的对照者的AFP值显著高于呈阴性的对照者（P<0.01），男性对照者的AFP值略高于女性对照者。