新型鬼臼毒素衍生物对多药耐药癌细胞的合成及抗肿瘤活性
Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells.
作者信息
Guo Yong-En, Chen Hong, Zuo Song, Liu Dai-Lin, Lu Yan-Ling, Lv Jing-Jing, Wen Shao-Peng, Zhang Tong-Cun
机构信息
Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, China.
出版信息
J Asian Nat Prod Res. 2011 May;13(5):417-24. doi: 10.1080/10286020.2011.568941.
PMID:21534039
Abstract
Seven novel 4β-N-substituted podophyllotoxin derivatives with indole rings were prepared and evaluated for cytotoxicity against human cancer cell lines HeLa, KB, KBV, K562, and K562/AO2. Most of them demonstrated improved antitumor activity and weak multidrug resistance compared to the drugs currently available.
摘要
制备了七种带有吲哚环的新型4β-N-取代鬼臼毒素衍生物，并评估了它们对人癌细胞系HeLa、KB、KBV、K562和K562/AO2的细胞毒性。与目前可用的药物相比，它们中的大多数表现出增强的抗肿瘤活性和较弱的多药耐药性。
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