高对映选择性和非对映选择性的钼催化氰基酯的不对称烯丙基烷基化反应。
A highly enantio- and diastereoselective molybdenum-catalyzed asymmetric allylic alkylation of cyanoesters.
机构信息
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
出版信息
J Am Chem Soc. 2011 Jun 1;133(21):8165-7. doi: 10.1021/ja2029602. Epub 2011 May 5.
PMID:21534526
Abstract
An efficient molybdenum-catalyzed asymmetric allylic alkylation (Mo-AAA) of cyanoester nucleophiles is reported. A number of highly functionalized branched cyanoesters containing a quaternary carbon stereocenter with a vicinal tertiary stereocenter are obtained. This method generates a number of functionalized cyanoesters in excellent yield and chemoselectivity in good to excellent diastereoselectivity and enantioselectivity.
摘要
本文报道了一种高效的氰基酯亲核试剂的钼催化不对称烯丙基烷基化反应（Mo-AAA）。该方法可以获得一系列含有季碳立体中心和相邻叔立体中心的高官能化支链氰基酯。该方法以优异的对映选择性和非对映选择性，获得了一系列功能化氰基酯，产率高，化学选择性好。
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