铱催化的带有官能团的有机锌溴化物的对映选择性烯丙基烷基化反应。
Iridium-catalyzed enantioselective allylic alkylation with functionalized organozinc bromides.
机构信息
Eidgenössische Technische Hochschule Zürich, HCI H335, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch.
出版信息
Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7644-7. doi: 10.1002/anie.201501851. Epub 2015 May 12.
Iridium-catalyzed enantioselective allylic alkylation of branched racemic carbonates with functionalized alkylzinc bromide reagents is described. Enabled by a chiral Ir/(P,olefin) complex, the method described allows allylic substitution with various primary and secondary alkyl nucleophiles with excellent regio- and enantioselectivities. The developed reaction was showcased in a concise, asymmetric synthesis of (-)-preclamol.
铱催化的手性支链外消旋碳酸酯与功能化的烷基溴化锌试剂的对映选择性烯丙基烷基化反应被描述。通过手性 Ir/(P，烯烃)配合物的作用，所描述的方法允许各种伯和仲烷基亲核试剂进行烯丙基取代，具有优异的区域和对映选择性。所开发的反应在(-)-preclamol 的简洁、不对称合成中得到了展示。
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