Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, People's Republic of China.
ACS Nano. 2011 May 24;5(5):3817-22. doi: 10.1021/nn200147n. Epub 2011 May 2.
Controlled graphene or its derivatives' assembly is of growing interest in many areas. However, achieving control over their assembly into precise and predictable architectures has been challenging and is still a bottleneck to their utilization. Herein, we report for the first time the use of DNA hybridization for the controllable assembly of a graphene nanosheet. Moreover, with the help of dynamic light scattering technique, we extended the above studies by exploiting the DNA-graphene dispersed sheets as highly ultrasensitive detection of oligonuleotides for the fabrication of a novel biosensing strategy, which shows high sensitivity and excellent selectivity. This work will show a new general route to graphene-based lamellar composite materials and would bring about advances in the research of graphene-based biofunctional materials for specific applications in biodiagnostics, nanoelectronics, and bionanotechnology.
控制石墨烯或其衍生物的组装在许多领域引起了越来越多的关注。然而，实现对其精确和可预测结构的组装控制一直具有挑战性，仍然是其利用的瓶颈。在此，我们首次报道了使用 DNA 杂交来可控组装石墨烯纳米片。此外，借助动态光散射技术，我们通过利用 DNA-石墨烯分散片作为寡核苷酸的高灵敏检测，扩展了上述研究，构建了一种新型的生物传感策略，该策略表现出高灵敏度和优异的选择性。这项工作将为基于石墨烯的层状复合材料展示一条新的通用途径，并将推动基于石墨烯的生物功能材料在生物诊断、纳米电子学和生物纳米技术等特定应用领域的研究进展。
