Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S3H6.
Inorg Chem. 2011 Dec 19;50(24):12338-48. doi: 10.1021/ic200663v. Epub 2011 May 2.
In 2006, our group reported the first metal-free systems that reversibly activate hydrogen. This finding was extended to the discovery of "frustrated Lewis pair" (FLP) catalysts for hydrogenation. It is this catalysis that is the focal point of this article. The development and applications of such FLP hydrogenation catalysts are reviewed, and some previously unpublished data are reported. The scope of the substrates is expanded. Optimal conditions and functional group tolerance are considered and applied to targets of potential commercial significance. Recent developments in asymmetric FLP hydrogenations are also reviewed. The future of FLP hydrogenation catalysts is considered.
2006 年，我们小组报道了首例可可逆活化氢气的无金属体系。这一发现扩展到了“受阻路易斯对”（FLP）氢化催化剂的发现。正是这种催化作用是本文的重点。本文综述了此类 FLP 氢化催化剂的发展和应用，并报道了一些以前未发表的数据。底物的范围得到了扩展。考虑并应用了最佳条件和官能团耐受性，以适用于具有潜在商业意义的目标。还综述了不对称 FLP 氢化的最新进展。对 FLP 氢化催化剂的未来进行了展望。
