Khan Imtiaz, Reed-Berendt Benjamin G, Melen Rebecca L, Morrill Louis C
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12356-12359. doi: 10.1002/anie.201808800. Epub 2018 Aug 24.
Herein we report the first catalytic transfer hydrogenation of silyl enol ethers. This metal free approach employs tris(pentafluorophenyl)borane and 2,2,6,6-tetramethylpiperidine (TMP) as a commercially available FLP catalyst system and naturally occurring γ-terpinene as a dihydrogen surrogate. A variety of silyl enol ethers undergo efficient hydrogenation, with the reduced products isolated in excellent yields (29 examples, 82 % average yield).
在此，我们报道了硅基烯醇醚的首例催化转移氢化反应。这种无金属方法采用三（五氟苯基）硼烷和2,2,6,6-四甲基哌啶（TMP）作为市售的FLP催化剂体系，并使用天然存在的γ-萜品烯作为二氢替代物。多种硅基烯醇醚都能进行高效氢化反应，还原产物的分离产率优异（29个实例，平均产率82%）。
