Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN 55401, USA.
Clin Transplant. 2011 Jul-Aug;25(4):E415-21. doi: 10.1111/j.1399-0012.2011.01471.x. Epub 2011 Apr 28.
This manuscript presents a summary of the Symposium "Xenotransplantation, from the Lab to the Clinic," held at the XXIII International Congress of The Transplantation Society, August 2010. This Symposium was timely in view of recent developments in translational research in the field, and the initiation of clinical trials after a thorough review by regulatory authorities and scientific experts. Three experts presented an update on the status of preclinical research with the perspective of moving forward to clinical trials; first data from clinical trials using encapsulated porcine islet cells; and the regulatory aspects for clinical application of a xenotransplantation product.
本文总结了 2010 年第 XXIII 届国际移植学会大会上举办的专题研讨会“异种移植：从实验室到临床”的内容。鉴于该领域转化研究的最新进展，以及监管部门和科学专家进行全面审查后开始临床试验，此次研讨会恰逢其时。三位专家介绍了推进临床试验的临床前研究现状的最新信息；介绍了使用包封猪胰岛细胞的临床试验的首批数据；以及异种移植产品临床应用的监管方面。
