Karliner J S, Kagiya T, Simpson P C
Cardiology Section (III C), Veterans Administratin Medical Center, San Francisco, California 94121.
Experientia. 1990 Jan 15;46(1):81-4. doi: 10.1007/BF01955423.
In neonatal rat ventricular myocytes pretreatment with pertussis toxin did not affect 1 microM (-)-norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as measured either by protein radiolabelling or by myocardial cell protein content. Thus guanine nucleotide protein(s) ADP-ribosylated by pertussis toxin do not play a role in two alpha 1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of myocardial cell hypertrophy.
在新生大鼠心室肌细胞中，用百日咳毒素预处理并不影响1微摩尔（-）-去甲肾上腺素对肌醇磷酸的刺激，也不影响通过蛋白质放射性标记或心肌细胞蛋白质含量所测量的心肌细胞肥大。因此，被百日咳毒素ADP-核糖基化的鸟嘌呤核苷酸蛋白在两个α1-肾上腺素能受体介导的过程中不起作用，这两个过程分别是磷脂酰肌醇的转换和心肌细胞肥大的诱导。
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