Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Jiading District, Shanghai 201800, China.
Colloids Surf B Biointerfaces. 2011 Aug 1;86(1):218-24. doi: 10.1016/j.colsurfb.2011.04.004. Epub 2011 Apr 9.
Bioactive PLLA/surface-grafted silica (g-SiO₂) nanocomposite scaffolds were fabricated by solid-liquid phase separation method. And solid PLLA/g-SiO₂ nanocomposite films were prepared by solution casting method. A series of parallel tube-like morphology and internal ladder-like structure of PLLA/g-SiO₂ nanocomposite scaffolds were observed by SEM. The formation of bone-like apatite in the simulated body fluid (SBF) was characterized by XRD, IR, SEM, EDS and weight measurement. The silica incorporation favors the formation of apatite. The growth of apatite with immersion time is found on the surfaces of both the PLLA/g-SiO₂ nanocomposite scaffolds and the films. The potential mechanism is that silanol groups of g-SiO₂ in the nanocomposites serve as nucleation sites for the formation of bone-like apatite crystals.
采用固-液相分离法制备了具有生物活性的 PLLA/表面接枝二氧化硅（g-SiO₂）纳米复合材料支架。采用溶液浇铸法制备了 PLLA/g-SiO₂纳米复合材料薄膜。SEM 观察到 PLLA/g-SiO₂纳米复合材料支架具有一系列平行管状形态和内部梯形结构。通过 XRD、IR、SEM、EDS 和重量测量对模拟体液（SBF）中形成的类骨磷灰石进行了表征。二氧化硅的掺入有利于磷灰石的形成。在 PLLA/g-SiO₂纳米复合材料支架和薄膜的表面都发现了随浸泡时间增长的磷灰石的生长。潜在的机制是纳米复合材料中的 g-SiO₂的硅醇基团作为形成类骨磷灰石晶体的成核位点。
