London Regional Cancer Program, London, Ontario N6A 4L6, Canada.
Genes Dev. 2011 May 1;25(9):889-94. doi: 10.1101/gad.2050411.
The Hippo pathway coordinates organ size and cell proliferation. The retinoblastoma family of proteins regulates progression through the G0/G1 phase of the cell cycle. Disruption of either pathway contributes to cancer formation. Three recent studies in Genes & Development reveal how cellular proliferation is coordinated between these pathways. Here we discuss the implications of these studies and the new questions that they raise.
Hippo 通路协调器官大小和细胞增殖。视网膜母细胞瘤家族蛋白调节细胞周期的 G0/G1 期进展。这两种途径的任何一种的破坏都会导致癌症的形成。最近在《基因与发育》杂志上的三项研究揭示了这两种途径之间的细胞增殖是如何协调的。在这里，我们将讨论这些研究的意义以及它们提出的新问题。
