Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
Schizophr Bull. 2012 Sep;38(5):1040-9. doi: 10.1093/schbul/sbr017. Epub 2011 May 2.
Neuroimaging studies in humans have implicated both dysfunction of the medial temporal lobe (MTL) and the dopamine system in psychosis, but the relationship between them is unclear. We addressed this issue by measuring MTL activation and striatal dopaminergic function in individuals with an At Risk Mental State (ARMS) for psychosis, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), respectively.
Thirty-four subjects (20 ARMS and 14 Controls), matched for age, gender, digit span performance, and premorbid IQ, were scanned using fMRI, while performing a verbal encoding and recognition task, and using 18F-DOPA PET. All participants were naïve to antipsychotic medication.
ARMS subjects showed reduced MTL activation when encoding words and made more false alarm responses for Novel words than controls. The relationship between striatal dopamine function and MTL activation during both verbal encoding and verbal recognition was significantly different in ARMS subjects compared with controls.
An altered relationship between MTL function and dopamine storage/synthesis capacity exists in the ARMS and may be related to psychosis vulnerability.
人类的神经影像学研究表明，精神分裂症既与内侧颞叶（MTL）功能障碍有关，也与多巴胺系统功能障碍有关，但两者之间的关系尚不清楚。我们通过功能磁共振成像（fMRI）和正电子发射断层扫描（PET）分别测量处于精神病高危状态（ARMS）的个体的 MTL 激活和纹状体多巴胺能功能，来解决这个问题。
34 名受试者（20 名 ARMS 和 14 名对照组），年龄、性别、数字跨度表现和学前智商匹配，分别使用 fMRI 进行语言编码和识别任务，以及使用 18F-DOPA PET。所有参与者均未使用抗精神病药物。
ARMS 患者在编码单词时 MTL 激活减少，对新单词的假警报反应多于对照组。与对照组相比，ARMS 患者在语言编码和语言识别期间纹状体多巴胺功能与 MTL 激活之间的关系明显不同。
在 ARMS 中，MTL 功能和多巴胺储存/合成能力之间存在改变的关系，可能与精神病易感性有关。
