Department of Psychiatry, Faculty of Medicine, Saga University, Saga, Japan.
Int J Geriatr Psychiatry. 2012 Mar;27(3):321-6. doi: 10.1002/gps.2729. Epub 2011 Apr 27.
The aim of the study was to examine the association of saliva levels of 3-methoxy-4-hydroxyphenylglycol (sMHPG) with a later depressive state in older people living in a rural community.
Baseline sMHPG levels were measured in 214 older subjects followed by completion of the Beck Depression Inventory (BDI) from 2004 to 2006 (time A). The same cohort underwent BDI again from 2007 to 2009 (time B).
One hundred forty-four subjects (44 men, 100 women) were reassessed by the BDI. Baseline sMHPG levels in men with a BDI score of ≤9 at time A and a BDI score of ≥10 at time B were significantly higher than those in men with a BDI score of ≤9 at times A and B. In men, there was a significant correlation between baseline sMHPG levels and BDI score at time B (r = 0.40, p = 0.007) but not at time A (r = 0.29, p = 0.06). This association was not significant in women.
These data indicate that high sMHPG levels at time A could be associated with a later depressive state in older men living in a community.
本研究旨在探讨社区居住的老年人唾液中 3-甲氧基-4-羟基苯乙二醇（sMHPG）水平与随后出现抑郁状态的相关性。
对 214 名老年人进行基线 sMHPG 水平测量，随后于 2004 年至 2006 年（时间 A）完成贝克抑郁量表（BDI）。同一队列于 2007 年至 2009 年（时间 B）再次接受 BDI 评估。
144 名受试者（44 名男性，100 名女性）接受了 BDI 的重新评估。在时间 A 时 BDI 评分≤9 分且时间 B 时 BDI 评分≥10 分的男性，其基线 sMHPG 水平显著高于时间 A 和 B 时 BDI 评分均≤9 分的男性。在男性中，基线 sMHPG 水平与时间 B 的 BDI 评分呈显著相关（r = 0.40，p = 0.007），但与时间 A 的 BDI 评分无关（r = 0.29，p = 0.06）。在女性中，这种相关性不显著。
这些数据表明，社区居住的老年男性在时间 A 时 sMHPG 水平较高可能与随后出现抑郁状态有关。
