Nabeta Hiromi, Mizoguchi Yoshito, Matsushima Jun, Imamura Yoshiomi, Watanabe Itaru, Tateishi Tetsuya, Kojima Naoki, Kawashima Toshiro, Yamada Shigeto, Monji Akira
Department of Psychiatry, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Japan.
Department of Psychiatry, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Japan.
J Affect Disord. 2014 Apr;158:85-9. doi: 10.1016/j.jad.2014.02.003. Epub 2014 Feb 10.
Late-life depressive disorder is becoming an important issue in health economics in the world, as it has been reported to be one of major risk factors for incidence of dementia. Identification of predictive markers associated with depression in later life is therefore of high priority in public health. The aim of the study was to examine the association of salivary cortisol levels with a later depressive state in elderly healthy people living in a rural Japan community.
Salivary cortisol levels were measured in 68 elderly healthy people (24 men; 44 women) followed by completion of the BDI, MMSE, and FAB from 2004 to 2006. The same cohort underwent BDI again from 2007 to 2009.
In healthy elderly women subject, a significant positive correlation was found between salivary cortisol levels at baseline and BDI scores at follow-up, but not at baseline. Salivary cortisol levels at baseline were not correlated with the score of either MMSE or FAB. When the cut-off point of BDI scores were set at 20/21, logistic regression analyses revealed that salivary cortisol levels at baseline had a significant positive relationship with a later depressive state. Age and gender were also significantly related with a later depressive state.
The present study involves small number of participants.
Higher salivary cortisol levels were associated with a later depressive state in elderly healthy women living in rural community. Salivary cortisol might be a predictive marker for a later depressive state in elderly women.
晚年抑郁症正成为全球卫生经济学中的一个重要问题，因为据报道它是痴呆症发病的主要风险因素之一。因此，识别与晚年抑郁症相关的预测标志物是公共卫生领域的高度优先事项。本研究的目的是调查日本农村社区老年健康人群唾液皮质醇水平与晚年抑郁状态之间的关联。
2004年至2006年，对68名老年健康人群（24名男性；44名女性）测量唾液皮质醇水平，随后完成贝克抑郁量表（BDI）、简易精神状态检查表（MMSE）和额叶评估量表（FAB）。同一队列在2007年至2009年再次接受BDI评估。
在健康老年女性受试者中，发现基线时的唾液皮质醇水平与随访时的BDI评分之间存在显著正相关，但基线时不存在。基线时的唾液皮质醇水平与MMSE或FAB评分均无相关性。当将BDI评分的临界值设定为20/21时，逻辑回归分析显示基线时的唾液皮质醇水平与晚年抑郁状态存在显著正相关。年龄和性别也与晚年抑郁状态显著相关。
本研究的参与者数量较少。
在生活在农村社区的老年健康女性中，较高的唾液皮质醇水平与晚年抑郁状态相关。唾液皮质醇可能是老年女性晚年抑郁状态的预测标志物。
