Defrance J F, Stanley J C, Marchand J E, Chronister R B
Ciba Found Symp. 1977(58):109-26. doi: 10.1002/9780470720394.ch7.
Acutely prepared rabbits were used to study, electrophysiologically, tetanic and post-tetanic potentiation of the pathway from the medial septal region to hippocampal field CA1. It was found that tetanic potentiation, evoked by short stimulus trains, was maximal at 6--8 Hz. Responses recovered from post-tetanic potentiation in 5--35 seconds. Acetylcholine, physostigmine, and cyclic GMP each had an excitatory effect on pyramidal cell responses when applied in stratum radiatum. The time course studies showed that these effects outlasted the duration of the injection current by many minutes. Phosphodiesterase inhibitors (e.g., isobutyl methyl xanthine) prolonged the time course of recovery with test responses which were post-tetanically potentiated. K+, on the other hand, selectively enhanced tetanic potentiation. It is suggested, with respect to the potentiation phenomena, that K+ acted primarily presynaptically to facilitate transmitter release, whereas cyclic GMP acted primarily postsynaptically for the enhancement of pyramidal cell excitability.
使用急性制备的兔子，通过电生理学方法研究从内侧隔区到海马CA1区的通路的强直和强直后增强。发现由短刺激串诱发的强直增强在6-8Hz时最大。强直后增强的反应在5-35秒内恢复。乙酰胆碱、毒扁豆碱和环鸟苷酸在辐射层应用时，对锥体细胞反应均有兴奋作用。时程研究表明，这些作用在注射电流持续时间之后还持续许多分钟。磷酸二酯酶抑制剂（如异丁基甲基黄嘌呤）延长了强直后增强的测试反应的恢复时程。另一方面，钾离子选择性地增强强直增强。关于增强现象，有人提出，钾离子主要作用于突触前促进递质释放，而环鸟苷酸主要作用于突触后增强锥体细胞兴奋性。
