Clement-Cormier Y, DeFrance J, Divakaran P, Stanley J, Taber K, Marchand J
J Neurosci Res. 1980;5(6):531-6. doi: 10.1002/jnr.490050608.
Biochemical studies on the hippocampus of acutely prepared rabbits revealed more than twofold increases in cyclic GMP levels following tetanic potentiation of the pathway from the medial septal region to CA1 pyramidal cells. Diazepam, administered intravenously, prevented the elevation in cyclic GMP levels in this region and also attenuated the post-tetanic potentiation seen following the presentation of trains at frequencies within theta rhythm. The results imply a modulatory role for cyclic nucleotides in the enhancement of pyramidal cell excitability and suggest that the biochemical mechanism for the psychoactive benzodiazepines may well include the suppression of cyclic GMP levels.
对急性制备的兔子海马体进行的生化研究表明，在内侧隔区至CA1锥体细胞的通路发生强直增强后，环鸟苷酸（cGMP）水平增加了两倍多。静脉注射地西泮可阻止该区域cGMP水平的升高，并且还减弱了以θ节律频率给予串刺激后出现的强直后增强。这些结果表明环核苷酸在增强锥体细胞兴奋性方面具有调节作用，并提示精神活性苯二氮䓬类药物的生化机制很可能包括抑制cGMP水平。
