School of Mathematics, University of Birmingham, Birmingham, United Kingdom.
Biophys J. 2011 May 4;100(9):2318-20; discussion 2321-4. doi: 10.1016/j.bpj.2011.03.014.
A recent study by Elgeti et al. used multiparticle collision dynamics to simulate a long-standing problem: the approach of sperm to surfaces, and subsequent accumulation. The authors highlight differences in their predictions with those of the earlier Stokes flow simulations of Smith et al. attributing the differences to methodological flaws in the earlier article. In this Comment, we discuss the criticisms leveled in detail, and review some recently published work that shows how species-specific details of cell morphology provides a more likely explanation for the differing predictions of the two studies. We also highlight experimental work that supports the study of Smith et al.
最近，Elgeti 等人利用多粒子碰撞动力学模拟了一个长期存在的问题：精子接近表面以及随后的聚集。作者强调了他们的预测与 Smith 等人之前的 Stokes 流模拟的差异，并将这些差异归因于早期文章中的方法缺陷。在本评论中，我们详细讨论了这些批评，并回顾了最近发表的一些工作，这些工作表明细胞形态的特定于物种的细节如何为这两项研究的不同预测提供了更可能的解释。我们还强调了支持 Smith 等人研究的实验工作。
