Navascués Ana, Rodríguez Irene, Repáraz Jesús, Salvo Soledad, Gil-Setas Alberto, Martínez Peñuela José María
Servicio de Microbiología, Complejo Hospitalario de Navarra, Pamplona, España.
Rev Iberoam Micol. 2011 Oct-Dec;28(4):194-7. doi: 10.1016/j.riam.2011.03.009. Epub 2011 Apr 14.
Histoplasmosis is a fungal infection caused by the dimorphic fungi Histoplasma capsulatum. Its incidence in Spain has increased in recent years, mainly due to the increased presence of immigrants from Latin America and increased travel to the continent for tourism and cooperation. Our aim was to review the clinical characteristics of cases of histoplasmosis diagnosed in our hospital during the last six years.
We diagnosed 4 cases from 4 patients from South America, 3 of whom were HIV positive and 1 diagnosed with dermatomyositis was treated with immunosuppressive drugs. The laboratory diagnosis was carried out by histological and microbiological study, by culture and specific PCR directly on the sample.
As it is an imported infection there needs to be a high level of suspicion and a detailed history taken to get a diagnosis. This infection requires a differential diagnosis between febrile syndrome in immunosuppressed patients, both HIV positive and immunosuppressive therapy, which originate from endemic areas, or who have a history of staying in them.
组织胞浆菌病是一种由双相真菌荚膜组织胞浆菌引起的真菌感染。近年来其在西班牙的发病率有所上升,主要原因是来自拉丁美洲的移民数量增加以及前往该大陆旅游和合作的人数增多。我们的目的是回顾过去六年在我院诊断的组织胞浆菌病病例的临床特征。
我们诊断了4例来自南美洲的患者,其中3例为HIV阳性,1例诊断为皮肌炎且正在接受免疫抑制药物治疗。实验室诊断通过组织学和微生物学研究、培养以及直接对样本进行特异性PCR来进行。
由于这是一种输入性感染,需要高度怀疑并详细询问病史以做出诊断。对于免疫抑制患者(包括HIV阳性患者和接受免疫抑制治疗的患者)出现的发热综合征,需要进行鉴别诊断,这些患者来自流行地区或有在流行地区停留的病史。