Barrasso R
Hôpital de l'Institut Pasteur, Paris.
Rev Prat. 1990 Jan 1;40(1):9-11.
Numerous epidemiological studies have made it possible to isolate groups of women at risk or developing an epidermoid carcinoma of the uterine cervix. Among the factors studied, age at the time of the first sexual intercourse and number of male partners were found to be statistically significant factors. No study has yet proved that smegma facilitates cancer and that circumcision may prevent its occurrence. However, the importance of the "male factor" has been enhanced by many studies suggesting the possibility of an oncogenic factor transmissible by sexual intercourse. Several data suggest that some types of human papillomavirus are the necessary, if not sufficient, factors of cervical oncogenesis. Some types of herpes virus, notably HPV 16, can be identified in the majority of invasive cancers and their direct precursors: intraepithelial neoplasias. The carcinogenic role of papillomaviruses in animals ans in laboratory experiments supports the theory that these sexually transmissible viruses are involved in the origin of epidermoid cervical carcinoma.
众多流行病学研究已能够确定有患子宫颈表皮样癌风险或正在患这种癌症的女性群体。在研究的诸多因素中，首次性交时的年龄和男性伴侣数量被发现是具有统计学意义的因素。尚无研究证明包皮垢会促进癌症发生以及包皮环切术可预防其发生。然而，许多研究提示存在可通过性交传播的致癌因素，这凸显了“男性因素”的重要性。一些数据表明，某些类型的人乳头瘤病毒即便不是导致宫颈癌发生的充分因素，也是必要因素。在大多数浸润性癌及其直接前驱病变（上皮内瘤变）中可识别出某些类型的疱疹病毒，尤其是人乳头瘤病毒16型。乳头瘤病毒在动物及实验室实验中的致癌作用支持了这样一种理论，即这些性传播病毒与子宫颈表皮样癌的起源有关。
