Penna C, Fallani M G, Cariti G, Bracco G L, Sensi G, Marchionni M
Minerva Ginecol. 1989 Jan;41(1):9-15.
Since the last century, epidemiological studies of cervical carcinoma have shown a close link with sexual activity and in particular with promiscuity starting at an early age. Aetiological research has therefore concentrated on identifying sexually transmitted pathogens. In recent years studies have focused on the apparently significant role of HSV and particularly HPV in the aetiopathogenesis of this tumour. After the first cytohistological findings the HPV-cervical cancer link has been confirmed by electron microscopy, immunohistochemical studies and hybridisation of viral DNA. The identification of different HPV types presenting varying degrees of oncogenic risk offers the prospect of reaching a reliable prognosis on the basis of the particular virus identified in the lesion. The hypothesis that the virus has a decisive influence on the biology of th tumour is also intriguing: findings on the incidence and course of cervical cancer in the youngest women seems to suggest tha HPV may be a fundamental tumour growth factor.
自上个世纪以来，宫颈癌的流行病学研究表明其与性活动密切相关，尤其是与早年开始的滥交有关。因此，病因学研究集中在鉴定性传播病原体上。近年来，研究聚焦于单纯疱疹病毒（HSV），尤其是人乳头瘤病毒（HPV）在该肿瘤病因发病机制中明显的重要作用。在首次细胞组织学发现之后，HPV与宫颈癌的关联已通过电子显微镜、免疫组织化学研究及病毒DNA杂交得以证实。鉴定出具有不同致癌风险程度的不同HPV类型，为基于病变中鉴定出的特定病毒得出可靠的预后提供了前景。病毒对肿瘤生物学具有决定性影响这一假说也很吸引人：最年轻女性宫颈癌发病率和病程的研究结果似乎表明HPV可能是一种基本的肿瘤生长因子。
