Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, Italy.
Dermatology. 2011;222(3):225-30. doi: 10.1159/000327376. Epub 2011 Apr 30.
T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature.
We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up.
The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement.
Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.
以皮肤为主要表现的 T 细胞/组织细胞丰富性大 B 细胞淋巴瘤（THRLBCL）是一种极其罕见的疾病，文献中仅零星报道过一些病例。
我们在此报告一例具有自我愈合特征的原发性皮肤 THRLBCL 病例，并进行了 24 个月的随访。
病变为皮肤皮下界限清楚的溃疡性结节。进行了组织学检查，包括免疫组织化学、分子分析和比较基因组杂交。全面分期检查排除了继发累及。
我们的病例值得注意，因为这是第二例有明确记录的原发性皮肤 THRLBCL，我们观察到皮肤病变完全自行消退，没有复发或疾病扩散。根据文献，我们强调肿瘤微环境在我们的病例中可能发挥了重要作用，阻止了淋巴瘤的生长。此外，该病例支持了这样一种观点，即主要表现为皮肤的 THRLBCL 总体预后良好。
