Boyce E G, Cookson E T, Bond W S
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy and Science, PA 19104.
DICP. 1990 Jan;24(1):19-21. doi: 10.1177/106002809002400103.
We report the case of a young woman with Crohn's disease who developed a debilitating peripheral neuropathy when treated with metronidazole 2000 mg/d for 50 days. The patient's neuropathy improved considerably after the discontinuation of metronidazole, but still persists two years later. The current literature on this topic is reviewed. Reports such as this one underscore the need to closely monitor the neurologic status of patients undergoing chronic treatment with metronidazole.
我们报告了一例患有克罗恩病的年轻女性病例，该患者在接受每日2000毫克甲硝唑治疗50天后出现了使人衰弱的周围神经病变。停用甲硝唑后，患者的神经病变有了显著改善，但两年后仍持续存在。本文对该主题的现有文献进行了综述。像这样的报告强调了密切监测接受甲硝唑慢性治疗患者神经状态的必要性。
