Coxon A, Pallis C A
J Neurol Neurosurg Psychiatry. 1976 Apr;39(4):403-5. doi: 10.1136/jnnp.39.4.403.
Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively. The drug, widely used in gastroenterological and gynaecological practice, has not hitherto been considered neurotoxic. The implications are stressed in relation to the differential diagnosis of patients with gastroenterological disorders who develop peripheral neuropathy.
本文描述了两名患者,他们分别在摄入30.6克和114克甲硝唑后出现感觉神经病变。这种药物广泛应用于胃肠病学和妇科领域,此前一直未被认为具有神经毒性。文中强调了这对于患有胃肠疾病并出现周围神经病变患者的鉴别诊断的意义。