自噬在肝脏生理和病理生理中的作用。
Role of autophagy in liver physiology and pathophysiology.
作者信息
Ding Wen-Xing
机构信息
Wen-Xing Ding, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, Kansas, KS 66160, United States.
出版信息
World J Biol Chem. 2010 Jan 26;1(1):3-12. doi: 10.4331/wjbc.v1.i1.3.
Abstract
Autophagy is a highly conserved intracellular degradation pathway by which bulk cytoplasm and superfluous or damaged organelles are enveloped by double membrane structures termed autophagosomes. The autophagosomes then fuse with lysosomes for degradation of their contents, and the resulting amino acids can then recycle back to the cytosol. Autophagy is normally activated in response to nutrient deprivation and other stressors and occurs in all eukaryotes. In addition to maintaining energy and nutrient balance in the liver, it is now clear that autophagy plays a role in liver protein aggregates related diseases, hepatocyte cell death, steatohepatitis, hepatitis virus infection and hepatocellular carcinoma. In this review, I discuss the recent findings of autophagy with a focus on its role in liver pathophysiology.
摘要
自噬是一种高度保守的细胞内降解途径，通过该途径，大量细胞质以及多余或受损的细胞器被称为自噬体的双膜结构包裹。然后，自噬体与溶酶体融合以降解其内容物，产生的氨基酸随后可以循环回到细胞质中。自噬通常在营养剥夺和其他应激源的刺激下被激活，并且存在于所有真核生物中。除了维持肝脏中的能量和营养平衡外，现在很清楚自噬在与肝脏蛋白质聚集体相关的疾病、肝细胞死亡、脂肪性肝炎、肝炎病毒感染和肝细胞癌中发挥作用。在这篇综述中，我将讨论自噬的最新研究发现，重点是其在肝脏病理生理学中的作用。
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本文引用的文献
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