de Barreda Elena Gomez, Avila Jesús
Elena Gomez de Barreda, Jesús Avila, Centro de Biologia Molecular Severo Ochoa, Spanish Network of Excellence on Neurodegenerative Diseases, Campus de Cantoblanco, 28049 Madrid, Spain.
World J Biol Chem. 2010 May 26;1(5):81-4. doi: 10.4331/wjbc.v1.i5.81.
Tau is an intracellular protein, found mainly in neurons, but it can also be found in the extracellular space in pathological situations. Here we discuss whether intracellular tau, in aggregated form or modified by phosphorylation, could be toxic inside a neuron. On the other hand, it has been proposed that extracellular tau could be toxic. In this review, we address the question if the elimination of tau would be a possible therapeutic method to avoid tauopathy disorder and we suggest ways to eliminate intracellular and extracellular tau as treatment.
tau蛋白是一种细胞内蛋白，主要存在于神经元中，但在病理情况下也可出现在细胞外空间。在此我们讨论聚集形式或经磷酸化修饰的细胞内tau蛋白在神经元内部是否具有毒性。另一方面，有人提出细胞外tau蛋白可能具有毒性。在这篇综述中，我们探讨消除tau蛋白是否可能是一种避免tau蛋白病紊乱的治疗方法，并提出消除细胞内和细胞外tau蛋白作为治疗手段的方法。
