关于氮杂-Morita-Baylis-Hillman 反应的机理：ESI-MS 截获独特的新中间体。
On the mechanism of the aza-Morita-Baylis-Hillman reaction: ESI-MS interception of a unique new intermediate.
机构信息
Laboratory of Synthesis of Natural Products and Drugs, University of Campinas-UNICAMP, Campinas, SP, Brazil.
出版信息
Chem Commun (Camb). 2011 Jun 21;47(23):6593-5. doi: 10.1039/c1cc10678c. Epub 2011 May 3.
PMID:21541415
Abstract
Solutions of aza-Morita-Baylis-Hillman (aza-MBH) reactions were directly monitored by ESI(+)-MS(/MS) spectrometry to obtain information on their mechanism. A unique bis-sulfonamide intermediate was intercepted and characterized and, based on this novel species, a mechanism that rationalizes the uniqueness of aza-MBH reactions is proposed.
摘要
aza-Morita-Baylis-Hillman（aza-MBH）反应的溶液通过 ESI(+)-MS(/MS) 光谱直接监测，以获得有关其机制的信息。截获并表征了独特的双磺酰胺中间体，并基于该新物种，提出了合理化 aza-MBH 反应独特性的机制。
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