Mehara Jaya, Roithová Jana
Institute for Molecules and Materials, Radboud University Heyendaalseweg 135 6525 AJ Nijmegen The Netherlands
Chem Sci. 2020 Oct 20;11(44):11960-11972. doi: 10.1039/d0sc04754f.
Development of new reactions requires finding and understanding of novel reaction pathways. In challenging reactions such as C-H activations, these pathways often involve highly reactive intermediates which are the key to our understanding, but difficult to study. Mass spectrometry has a unique sensitivity for detecting low abundant charged species; therefore it is increasingly used for detection of such intermediates in metal catalysed- and organometallic reactions. This perspective shows recent developments in the field of mass spectrometric research of reaction mechanisms with a special focus on going beyond mass-detection. Chapters discuss the advantages of collision-induced dissociation, ion mobility and ion spectroscopy for characterization of structures of the detected intermediates. In addition, we discuss the relationship between the condensed phase chemistry and mass spectrometric detection of species from solution.
新反应的开发需要发现并理解新的反应途径。在诸如C-H活化等具有挑战性的反应中,这些途径通常涉及高活性中间体,它们是我们理解反应的关键,但却难以研究。质谱对检测低丰度带电物种具有独特的灵敏度;因此,它越来越多地用于检测金属催化反应和有机金属反应中的此类中间体。本综述展示了反应机理质谱研究领域的最新进展,特别关注超越质量检测的内容。各章节讨论了碰撞诱导解离、离子淌度和离子光谱在表征所检测中间体结构方面的优势。此外,我们还讨论了凝聚相化学与溶液中物种的质谱检测之间的关系。