Bojanic K, Acke E, Jones B R
Veterinary Clinic Fiziovet, Zagreb, Croatia.
N Z Vet J. 2011 May;59(3):115-22. doi: 10.1080/00480169.2011.567964.
Congenital hypothyroidism is a rare and underdiagnosed congenital endocrine disorder in dogs and cats and the true incidence is unknown. The disorder may cause a range of clinical signs depending on the primary defect, which affect production of thyroid hormones; some cases present when adult. Hallmark clinical signs of congenital hypothyroidism are mental impairment and skeletal developmental abnormalities, resulting in disproportionate dwarfism; goitre may or may not be present. Documented causes of congenital hypothyroidism in dogs include deficiency of, or unresponsiveness to, thyrotropin-releasing hormone (TRH) or thyroid-stimulating hormone (TSH), thyroid dysgenesis, dyshormonogenesis and iodine deficiency. In cats, TSH unresponsiveness, thyroid dysgenesis, dyshormonogenesis and iodine deficiency have been confirmed. Adequate replacement therapy results in a successful outcome in the majority of cases, especially when started early in life, as permanent developmental abnormalities can be prevented. This review describes reported cases in dogs and cats, diagnostic investigation, and recommendations for treatment.
先天性甲状腺功能减退是一种在犬猫中罕见且诊断不足的先天性内分泌疾病，其真实发病率尚不清楚。该疾病可能会根据影响甲状腺激素产生的原发性缺陷而导致一系列临床症状；有些病例在成年时才出现。先天性甲状腺功能减退的标志性临床症状是智力障碍和骨骼发育异常，导致不成比例的侏儒症；甲状腺肿可能存在也可能不存在。犬先天性甲状腺功能减退的已记录病因包括促甲状腺激素释放激素（TRH）或促甲状腺激素（TSH）缺乏或无反应、甲状腺发育不全、激素合成障碍和碘缺乏。在猫中，已证实存在TSH无反应、甲状腺发育不全、激素合成障碍和碘缺乏。在大多数情况下，充分的替代疗法会取得成功，尤其是在生命早期开始治疗时，因为可以预防永久性发育异常。这篇综述描述了犬猫的报告病例、诊断检查以及治疗建议。
