Golinelli Stefania, Tardo Antonio Maria, Vecchiato Carla Giuditta, Guido Eleonora Anicito, Perfetti Simone, Diana Alessia, Fracassi Federico
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.
Vet Sci. 2022 Mar 16;9(3):140. doi: 10.3390/vetsci9030140.
Congenital hypothyroidism is uncommon in cats. This case report describes weight gain, clinicopathological and radiographic changes after early diagnosis and treatment of congenital hypothyroidism in three British shorthair cats’ siblings. Data were assessed at 53 (diagnosis), 83, 185 and 365 days of age. Correlations between serum insulin-like growth factor-1 (IGF-1) and body weight, levothyroxine dose, total thyroxine, and thyroid-stimulating hormone concentrations were evaluated. The body weights of the congenital hypothyroid kittens were compared with those of their two healthy siblings and British shorthair kittens of the same age. At diagnosis, the congenital hypothyroid kittens showed a significantly lower body weight compared to the healthy siblings (p = 0.03). After diagnosis, oral levothyroxine supplementation was started. The difference in body weight was no longer observed after one month of treatment. The clinical signs, clinicopathological and radiographic abnormalities ameliorated after one month of treatment. IGF-1 concentration was significantly positively correlated with body weight (rs = 0.80, p < 0.002). In conclusion, resolution of the clinical signs, achieving a consistent within-breed weight, and improvement of the clinicopathological and radiographic parameters demonstrated the importance of the early diagnosis and treatment of feline congenital hypothyroidism.
先天性甲状腺功能减退症在猫中并不常见。本病例报告描述了3只英国短毛猫同胞幼崽先天性甲状腺功能减退症早期诊断和治疗后的体重增加、临床病理和影像学变化。在53日龄（诊断时）、83日龄、185日龄和365日龄时评估数据。评估了血清胰岛素样生长因子-1（IGF-1）与体重、左甲状腺素剂量、总甲状腺素和促甲状腺激素浓度之间的相关性。将先天性甲状腺功能减退的幼猫体重与其两只健康的同胞幼崽以及同龄的英国短毛猫幼崽的体重进行比较。诊断时，先天性甲状腺功能减退的幼猫体重明显低于健康的同胞幼崽（p = 0.03）。诊断后，开始口服补充左甲状腺素。治疗1个月后，体重差异不再明显。治疗1个月后，临床症状、临床病理和影像学异常均有所改善。IGF-1浓度与体重呈显著正相关（rs = 0.80，p < 0.002）。总之，临床症状的缓解、达到同品种内一致的体重以及临床病理和影像学参数的改善证明了猫先天性甲状腺功能减退症早期诊断和治疗的重要性。
