PROMEC Unit, Medical Research Council, Tygerberg, South Africa.
Nutr Cancer. 2011;63(4):600-10. doi: 10.1080/01635581.2011.539313.
Widespread consumption of herbal teas has stimulated interest in their role as cancer preventive agents. The present investigation monitored the modulation of methylbenzylnitrosamine (MBN)-induced esophageal squamous cell carcinogenesis by rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) herbal and Camellia sinensis teas in male F344 rats. The tumor multiplicity was significantly (P < 0.05) inhibited by unfermented honeybush (45.5%), green (50%), and black (36%) teas, while the other teas exhibited weaker effects (<30% inhibition). The mean total papilloma size was reduced by unfermented rooibos (87%), unfermented honeybush (94%), and fermented honeybush (74%) due to the absence of large papillomas (>10 mm(3)). Reduction of the mean total papilloma number correlated with the total polyphenol (TPP) (r = 0.79; P < 0.02) and flavanol/proanthocyanidin (FLAVA) (r = 0.89; P < 0.008) intake (mg/100 g body weight) of the teas and the FLAVA (r = 0.89; P < 0.04) and flavonol/flavones/xanthones (r = 0.99; P < 0.002) intake when considering only the herbal teas. A daily TPP intake threshold of 7 mg/100 g body weight existed below where no inhibition of papilloma development was observed. Fermentation of herbal teas reduced the inhibitory effects on papilloma development associated with a reduction in the polyphenolic constituents. The inhibitory effect of herbal teas on papilloma development is associated with different flavonoid subgroups and/or combination thereof.
广泛饮用草本茶已激发了人们对其作为癌症预防剂作用的兴趣。本研究监测了罗布斯茶（Aspalathus linearis）和霍桑茶（Cyclopia intermedia）草本茶以及茶树茶对雄性 F344 大鼠甲基苄基亚硝胺（MBN）诱导的食管鳞状细胞癌发生的调节作用。未发酵的霍桑茶（45.5％）、绿茶（50％）和黑茶（36％）显著（P <0.05）抑制了肿瘤多发性，而其他茶则表现出较弱的作用（<30％抑制）。由于不存在大的乳头瘤（>10 mm³），未发酵的罗布斯茶（87％）、未发酵的霍桑茶（94％）和发酵的霍桑茶（74％）降低了平均总乳头瘤的大小。平均总乳头瘤数的减少与茶的总多酚（TPP）（r = 0.79；P <0.02）和黄烷醇/原花青素（FLAVA）（r = 0.89；P <0.008）摄入量（mg/100 g 体重）相关，当仅考虑草本茶时，还与 FLAVA（r = 0.89；P <0.04）和类黄酮/黄酮醇/黄烷酮（r = 0.99；P <0.002）摄入量相关。每天 TPP 摄入量低于 7 mg/100 g 体重时，未观察到对乳头瘤发育的抑制作用。草本茶的发酵降低了与多酚成分减少相关的对乳头瘤发育的抑制作用。草本茶对乳头瘤发育的抑制作用与不同的类黄酮亚组和/或其组合有关。
