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[莱姆病与中枢神经系统脱髓鞘疾病]

[Lyme borreliosis and demyelinating disease of the central nervous system].

作者信息

Bazovská S, Durovská J, Pancák J, Záborská M, Derdáková M

机构信息

Ustav epidemiológie, Lekárska fakulta UK v Bratislave.

出版信息

Epidemiol Mikrobiol Imunol. 2011 Feb;60(1):45-7.

Abstract

A case report is presented of a 55-year-old patient diagnosed with a demyelinating disease of unclear etiology. The patient had Lyme borreliosis in 2004. Specific IgG antibodies against B. burgdorferi s. l. were detected in the serum. Intrathecal antibodies were not found in the cerebrospinal fluid, but the presence of B. garinii DNA was confirmed by PCR analysis. It can be hypothesized that the borrelial persistence in the body may have been one of the triggers of the autoimmune process resulting in demyelination of the central nervous system (CNS).

摘要

本文报告了一例55岁被诊断为病因不明的脱髓鞘疾病患者。该患者在2004年患有莱姆病。血清中检测到抗狭义伯氏疏螺旋体的特异性IgG抗体。脑脊液中未发现鞘内抗体,但通过PCR分析证实存在伽氏疏螺旋体DNA。可以推测,伯氏疏螺旋体在体内的持续存在可能是导致中枢神经系统脱髓鞘的自身免疫过程的触发因素之一。

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