Durovska Judita, Bazovska Sylvia, Pancak Jaroslav, Zaborska Magdalena, Derdakova Marketa, Traubner Pavel
1st Department of Neurology, Comenius University, Bratislava, Slovakia.
Neuro Endocrinol Lett. 2011;32(4):411-4.
The work describes three cases of patients at various ages, diagnosed for CNS demyelinating disease. The presence of specific antibodies to B. burgdorferi sensu lato, and findings of B. burgdorferi s.l. DNA, identified in one case as the genospecies B. garinii in the liquor, indicated previous experience with the infection. Presumably, persistence of borrelia in the organism could act as one of the autoimmune process triggers, resulting in the demyelinating disease.
该研究描述了三例不同年龄段被诊断为中枢神经系统脱髓鞘疾病的患者。在其中一例患者的脑脊液中发现了针对广义伯氏疏螺旋体的特异性抗体,以及广义伯氏疏螺旋体DNA,鉴定为基因种伽氏疏螺旋体,这表明患者曾有过该感染经历。据推测,伯氏疏螺旋体在体内的持续存在可能是自身免疫过程的触发因素之一,从而导致脱髓鞘疾病。