Valentová M, Mladosievicová B
Oddelenie klinickej patofyziológie LF UK v Bratislave, Slovenská republika.
Klin Onkol. 2011;24(1):18-22.
The modern treatment of testicular cancer has led to notable improvement in the prognosis of these patients. A significant number of testicular cancer survivors suffer from late effects of their treatment that can occur several years after the treatment. Cardiovascular late effects represent one of the most serious effects with respect to their life-threatening potential. Considering the higher risk of coronary heart disease, numerous studies have investigated the prevalence of cardiovascular risk factors in patients treated for testicular cancer. Higher prevalence of hypertension in patients after treatment for testicular cancer may be one of the reasons for their serious cardiovascular morbidity and mortality.The aim of this is to summarize the current knowledge on the impact of review treatment modalities used in testicular cancer therapy on prevalence of hypertension and its pathogenetic context. Both chemotherapy and radiotherapy are associated with increased prevalence of hypertension several years after completing the treatment. In patients treated with chemotherapy, hypertension is associated with administration of cisplatin. Cisplatin remains in organism for up to 20 years after administration and may lead to endothelial dysfunction. Regular and long-term monitoring of cardiovascular risk should be introduced to ensure better quality of life in these patients.
睾丸癌的现代治疗已使这些患者的预后有了显著改善。相当数量的睾丸癌幸存者遭受治疗的晚期效应，这些效应可能在治疗数年之后出现。心血管晚期效应就其危及生命的可能性而言是最严重的效应之一。鉴于冠心病风险较高，众多研究调查了接受睾丸癌治疗患者中心血管危险因素的患病率。睾丸癌治疗后患者中高血压患病率较高可能是其严重心血管发病率和死亡率的原因之一。本研究的目的是总结当前关于睾丸癌治疗中所用治疗方式对高血压患病率及其发病机制背景影响的知识。化疗和放疗在完成治疗数年之后均与高血压患病率增加相关。在接受化疗的患者中，高血压与顺铂的使用有关。顺铂在给药后可在体内留存长达20年，并可能导致内皮功能障碍。应开展定期和长期的心血管风险监测，以确保这些患者有更好的生活质量。
