Hu Jie, Chen Da-wei, Quan Dong-qin
School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yao Xue Xue Bao. 2011 Feb;46(2):227-31.
Rheological properties of poloxamer 407 (brand named Pluronic F127) were examined by changing shear rate, temperature and the recovery properties of apparent viscosity after heating for several times. The results indicated that poloxamer 407 aqueous solution showed a Newtonian behavior at a low concentration while it might be a pseudoplastic fluid when the concentration reached a certain point. The thixotropy and the sol-gel transition temperature decreased with increasing the concentration (it could be an in situ gel at body temperature when the concentration of poloxamer 407 up to 15.25%). The results that obtained from the theological data would be useful in the application of poloxamer 407 such as in situ gel preparation.
通过改变剪切速率、温度以及多次加热后表观粘度的恢复特性，研究了泊洛沙姆407（商品名普朗尼克F127）的流变学性质。结果表明，泊洛沙姆407水溶液在低浓度时表现出牛顿流体行为，而当浓度达到一定程度时可能为假塑性流体。触变性和溶胶-凝胶转变温度随浓度增加而降低（当泊洛沙姆407浓度高达15.25%时，在体温下可为原位凝胶）。从流变学数据获得的结果将有助于泊洛沙姆407在原位凝胶制备等方面的应用。
