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通过将泊洛沙姆与碳酸钙交联的海藻酸钠共混制备可注射性复合水凝胶。

Preparation of Injectable Composite Hydrogels by Blending Poloxamers with Calcium Carbonate-Crosslinked Sodium Alginate.

机构信息

School of Medicine Xi'an International University Xi'an 710077, Shaanxi China.

School of Chemical Engineering Northwest University Xi'an 710069, Shaanxi China.

出版信息

ChemistryOpen. 2020 Apr 6;9(4):451-458. doi: 10.1002/open.202000040. eCollection 2020 Apr.

DOI:10.1002/open.202000040
PMID:32269901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7136648/
Abstract

The effects of calcium carbonate-crosslinked sodium alginate on poloxamer hydrogels have been investigated. The mechanical strength, degradability, and thermal stability of hydrogels were characterized. The chemical and physical crosslinking in the composite hydrogels has resulted in an improvement of the compressive strength and elasticity of the hydrogels. These mixed hydrogels showed improved mechanical properties, elasticity, and stability as well as environmental responsiveness and injectability.

摘要

研究了碳酸钙交联海藻酸钠对泊洛沙姆水凝胶的影响。对水凝胶的机械强度、降解性和热稳定性进行了表征。复合水凝胶中的化学和物理交联导致水凝胶的抗压强度和弹性得到提高。这些混合水凝胶表现出改善的机械性能、弹性和稳定性以及环境响应性和可注射性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/601acc6238cf/OPEN-9-451-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/c0c01f0c22c1/OPEN-9-451-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/8c88f8071b30/OPEN-9-451-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/149257a2dc5e/OPEN-9-451-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/11089a447154/OPEN-9-451-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/04fd271190e0/OPEN-9-451-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/09bd179db221/OPEN-9-451-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/601acc6238cf/OPEN-9-451-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/c0c01f0c22c1/OPEN-9-451-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/8c88f8071b30/OPEN-9-451-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/149257a2dc5e/OPEN-9-451-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/11089a447154/OPEN-9-451-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/04fd271190e0/OPEN-9-451-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/09bd179db221/OPEN-9-451-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af95/7136648/601acc6238cf/OPEN-9-451-g007.jpg

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