Gawade Prasad, Markenson Glenn, Bsat Fadi, Healy Andrew, Pekow Penelope, Plevyak Michael
Division of Biostatistics and Epidemiology, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, USA.
J Reprod Med. 2011 Mar-Apr;56(3-4):95-102.
To evaluate the association of gestational weight gain with the cesarean delivery (CD) rate in term women undergoing induction of labor (IOL).
This is a retrospective cohort study of 2,495 consecutive term women from May 2005 to June 2008 admitted for IOL between 37 and 42 completed weeks of gestation. Labor induction ending in cesarean delivery was defined as a binary outcome. Weight gain during pregnancy was calculated by subtracting prepregnancy weight from weight recorded at delivery. Multiple gestation, malpresentation, stillbirth, planned CD and women with prior CD were excluded. Maternal and obstetric characteristics were examined as predictors of CD using multivariable logistic regression analyses.
The risk of CD increased by 13% (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.05-1.23) for each 5 kg increase in gestational weight gain. Other factors associated with an increased risk of CD included maternal age (OR per year 1.05, 95% CI 1.03-1.06), neonatal birth weight (OR 1.06 per 100 g, 95% CI 1.03-1.08), nulliparity (OR 9.13, 95% CI 7.00-11.90), Bishop score at admission < or = 5 (OR 2.3, 95% CI 1.90-2.90), male infant (OR 1.37, 95% CI 1.10-1.70) and unit increase in prepregnancy body mass index (OR 1.08, 95% CI 1.06-1.10).
The CD rate following labor induction increases significantly with increasing gestational weight gain even after controlling for possible confounding variables.
评估足月引产(IOL)女性的孕期体重增加与剖宫产(CD)率之间的关联。
这是一项回顾性队列研究,研究对象为2005年5月至2008年6月期间连续收治的2495名足月女性,她们在妊娠37至42周时接受引产。以剖宫产结束引产被定义为二元结局。孕期体重增加通过分娩时记录的体重减去孕前体重来计算。排除多胎妊娠、胎位异常、死产、计划剖宫产以及有剖宫产史的女性。使用多变量逻辑回归分析检查母体和产科特征作为剖宫产的预测因素。
孕期体重每增加5千克,剖宫产风险增加13%(比值比[OR]1.13,95%置信区间[CI]1.05 - 1.23)。与剖宫产风险增加相关的其他因素包括产妇年龄(每年OR 1.05,95% CI 1.03 - 1.06)、新生儿出生体重(每100克OR 1.06,95% CI 1.03 - 1.08)、初产(OR 9.13,95% CI 7.00 - 11.90)、入院时Bishop评分≤5(OR 2.3,95% CI 1.90 - 2.90)、男婴(OR 1.37,95% CI 1.10 - 1.70)以及孕前体重指数单位增加(OR 1.08,95% CI 1.06 - 1.10)。
即使在控制了可能的混杂变量后,引产术后的剖宫产率仍随孕期体重增加而显著升高。