Department of Neuro Pathology, University of Amsterdam and Epilepsy Institute, the Netherlands.
Epilepsia. 2011 May;52 Suppl 3:26-32. doi: 10.1111/j.1528-1167.2011.03033.x.
Over the past decade, an increasing number of observations indicate that activation of inflammatory processes occurs in variety of focal epilepsies. Understanding the feature and consequences of neuroinflammation, including the contribution to development and perpetuation of seizures, as well as to mood or cognitive dysfunction, is a major requisite for delineating its role in epilepsy. The present article discusses the most recent observations supporting the involvement of the inflammatory response in human focal epilepsy. It also evaluates emerging evidence concerning the possibility to identify epilepsy-associated inflammatory biomarkers in cerebrospinal fluid and serum, as well as the potential application of neuroimaging approaches to study the inflammatory reactions in chronic epilepsy patients in vivo, aiming to improve the recognition of appropriate patient populations who might benefit from antiinflammatory or immunomodulatory therapies.
在过去的十年中，越来越多的观察表明，炎症过程的激活发生在各种局灶性癫痫中。了解神经炎症的特征和后果，包括对发作的发展和持续以及情绪或认知功能障碍的贡献，是阐明其在癫痫中的作用的主要要求。本文讨论了最近的观察结果，这些结果支持炎症反应参与人类局灶性癫痫。它还评估了关于在脑脊液和血清中识别与癫痫相关的炎症生物标志物的可能性的新证据，以及神经影像学方法在研究慢性癫痫患者体内炎症反应中的潜在应用，旨在提高对可能受益于抗炎或免疫调节治疗的合适患者群体的认识。
