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治疗剂量下的致命性锂中毒——一例报告

Fatal lithium toxicity with therapeutic levels--a case report.

作者信息

Venkatarathnamma P N, Patil A R, Nanjundaiah N

机构信息

Sri Devaraj Urs Medical College, Karnataka, India.

出版信息

Int J Clin Pharmacol Ther. 2011 May;49(5):336-8. doi: 10.5414/cpp49336.

Abstract

For nearly five decades now, lithium has been used as a drug for treatment of bipolar affective disorder [1]. Adverse effects of lithium have been reported, but still lithium continues to be an effective prophylactic agent for bipolar disorder. Serious and fatal toxicity can occur with levels of lithium considered to be in the therapeutic range [2, 3, 4, 5, 6]. We are reporting a patient who was on lithium for bipolar disorder and was admitted with a history of sudden collapse following vomiting, and sinus bradycardia with ST-T changes. The patient expired with levels of lithium being within therapeutic range.

摘要

近五十年来,锂一直被用作治疗双相情感障碍的药物[1]。锂的不良反应已有报道,但它仍是双相情感障碍有效的预防药物。锂水平处于治疗范围内时也可能发生严重及致命毒性[2, 3, 4, 5, 6]。我们报告一名因双相情感障碍服用锂的患者,该患者因呕吐后突然晕倒、窦性心动过缓伴ST-T改变入院。患者在锂水平处于治疗范围内时死亡。

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