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治疗剂量锂诱导的窦房结功能障碍。

Lithium-induced sinus node dysfunction at therapeutic levels.

作者信息

Shetty Ranjan K, Vivek G, Parida Amrita, Chetty Shashikanth

机构信息

Department of Cardiology, Kasturba Medical College, Manipal, Karnataka, India.

出版信息

BMJ Case Rep. 2013 Jan 22;2013:bcr2012008107. doi: 10.1136/bcr-2012-008107.

DOI:10.1136/bcr-2012-008107
PMID:23345498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3603999/
Abstract

Lithium is used as an antimanic and mood-stabilising drug. It can cause various adverse effects such as nausea, vomiting, polyuria, fine tremors, myocarditis and arrhythmias. We are describing a case of lithium induced sinus-node dysfunction in a patient with serum lithium levels in therapeutic range.

摘要

锂被用作抗躁狂和情绪稳定药物。它可引起各种不良反应，如恶心、呕吐、多尿、细微震颤、心肌炎和心律失常。我们正在描述一例血清锂水平处于治疗范围内的患者发生锂诱导的窦房结功能障碍的病例。

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本文引用的文献

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Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced blockade of sodium channels to impaired pacemaker activity.治疗浓度下锂诱导的窦房结疾病：将锂诱导的钠通道阻滞与起搏活动受损联系起来。
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Unmasking of brugada syndrome by lithium.锂诱发的Brugada综合征的暴露
Circulation. 2005 Sep 13;112(11):1527-31. doi: 10.1161/CIRCULATIONAHA.105.548487. Epub 2005 Sep 6.
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Inherited disorders of voltage-gated sodium channels.电压门控钠通道的遗传性疾病。
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Heart rate variability and autonomic activity at rest and during exercise in various physiological conditions.不同生理条件下静息和运动时的心率变异性与自主神经活动。
Eur J Appl Physiol. 2003 Oct;90(3-4):317-25. doi: 10.1007/s00421-003-0953-9. Epub 2003 Sep 12.
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Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3507-12. doi: 10.1073/pnas.2627986100. Epub 2003 Mar 11.
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