UNESP, School of Veterinary Medicine and Animal Science, Department of Veterinary Hygiene and Public Health, Botucatu, SP, Brazil.
Res Vet Sci. 2012 Jun;92(3):396-400. doi: 10.1016/j.rvsc.2011.03.025. Epub 2011 May 4.
Considering the high prevalence of rabies in cattle, we aimed to evaluate the interference of colostral antibodies transferred to calves after birth and the benefit of administering an antirabies vaccination in two-month-old calves compared to vaccinating at 4 and 6 months of age. Calves born from females revaccinated against rabies during the third trimester of pregnancy were studied. Forty-eight hours after parturition, blood samples from dams and offspring were collected, and antirabies neutralizing antibody titers were analyzed using the Rapid Focus Fluorescent Inhibition Test. We found that all calves had similar titers of antibodies transferred through the colostrum. Furthermore, none of the calves presented a satisfactory serological response after the first vaccination, but all had an appropriate response after revaccination. This study demonstrates that antirabies vaccination should be recommended for calves at two months of age in endemic and epizootic situations.
鉴于狂犬病在牛群中的高流行率，我们旨在评估在小牛出生后通过初乳转移的抗体的干扰作用，以及与在 4 个月和 6 个月龄时相比，对 2 月龄小牛进行狂犬病疫苗接种的益处。研究了在妊娠晚期接受狂犬病加强免疫的母畜所产的小牛。分娩后 48 小时，采集母畜和后代的血液样本，并使用快速荧光灶抑制试验分析抗狂犬病中和抗体滴度。我们发现，所有小牛通过初乳转移的抗体滴度相似。此外，第一次接种后，没有一头小牛出现满意的血清学反应，但所有小牛在再次接种后都有适当的反应。这项研究表明，在流行和散发情况下，应建议对 2 月龄的小牛进行狂犬病疫苗接种。
