WormBase Group, The Wellcome Trust Sanger Institute, Hinxton, Cambs, UK.
Database (Oxford). 2011 May 3;2011:baq039. doi: 10.1093/database/baq039. Print 2011.
The Caenorhabditis elegans genome sequence was published over a decade ago; this was the first published genome of a multi-cellular organism and now the WormBase project has had a decade of experience in curating this genome's sequence and gene structures. In one of its roles as a central repository for nematode biology, WormBase continues to refine the gene structure annotations using sequence similarity and other computational methods, as well as information from the literature- and community-submitted annotations. We describe the various methods of gene structure curation that have been tried by WormBase and the problems associated with each of them. We also describe the current strategy for gene structure curation, and introduce the WormBase 'curation tool', which integrates different data sources in order to identify new and correct gene structures. Database URL: http://www.wormbase.org/.
十多年前，秀丽隐杆线虫基因组序列发布；这是第一个多细胞生物的基因组，而现在 WormBase 项目已经有十年的经验来管理这个基因组的序列和基因结构。作为线虫生物学的中央知识库之一，WormBase 继续使用序列相似性和其他计算方法以及文献和社区提交的注释信息来完善基因结构注释。我们描述了 WormBase 尝试过的各种基因结构管理方法以及它们各自存在的问题。我们还描述了当前的基因结构管理策略，并介绍了 WormBase 的“管理工具”，它集成了不同的数据源，以识别新的和正确的基因结构。数据库网址：http://www.wormbase.org/。
