More than inflammation: interleukin-1beta polymorphisms and the lipid metabolism.
作者信息
Netea Mihai G, Dinarello Charles A
出版信息
J Clin Endocrinol Metab. 2011 May;96(5):1279-81. doi: 10.1210/jc.2011-0685.
Abstract
摘要
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本文引用的文献
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Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice.针对白细胞介素 1β的单克隆抗体可减少体外动脉粥样硬化生物标志物，并抑制载脂蛋白 E 缺陷小鼠的动脉粥样硬化斑块形成。
Atherosclerosis. 2011 Jun;216(2):313-20. doi: 10.1016/j.atherosclerosis.2011.02.026. Epub 2011 Feb 24.
2
Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism.白细胞介素 1B 变体-1473G/C（rs1143623）影响甘油三酯和白细胞介素 6 的代谢。
J Clin Endocrinol Metab. 2011 May;96(5):E816-20. doi: 10.1210/jc.2010-2455. Epub 2011 Feb 9.
3
Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α.载脂蛋白-E 缺陷型小鼠缺乏骨髓来源的白细胞介素-1α可减少动脉粥样硬化和炎症细胞因子。
Biochem Biophys Res Commun. 2011 Feb 11;405(2):197-203. doi: 10.1016/j.bbrc.2011.01.008. Epub 2011 Jan 8.
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J Intern Med. 2011 Jan;269(1):16-28. doi: 10.1111/j.1365-2796.2010.02313.x.
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Cell Metab. 2010 Dec 1;12(6):593-605. doi: 10.1016/j.cmet.2010.11.011.
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Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis.脂肪酸与Toll样受体2结合通过ASC/半胱天冬酶1途径在尿酸单钠晶体诱导的痛风性关节炎中驱动白细胞介素-1β的产生。
Arthritis Rheum. 2010 Nov;62(11):3237-48. doi: 10.1002/art.27667.
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.NLRP3 炎性小体对于动脉粥样硬化的形成是必需的，并且可以被胆固醇晶体激活。
Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938.
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