广谱中和抗体对严重联合免疫缺陷马同源和异源马传染性贫血病毒感染的保护作用。
Protective effects of broadly neutralizing immunoglobulin against homologous and heterologous equine infectious anemia virus infection in horses with severe combined immunodeficiency.
机构信息
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA.
出版信息
J Virol. 2011 Jul;85(13):6814-8. doi: 10.1128/JVI.00077-11. Epub 2011 May 4.
Abstract
Using the equine infectious anemia virus (EIAV) lentivirus model system, we previously demonstrated protective effects of broadly neutralizing immune plasma in young horses (foals) with severe combined immunodeficiency (SCID). However, in vivo selection of a neutralization-resistant envelope variant occurred. Here, we determined the protective effects of purified immunoglobulin with more potent broadly neutralizing activity. Overall, protection correlated with the breadth and potency of neutralizing activity in vitro. Four of five SCID foals were completely protected against homologous challenge, while partial protection occurred following heterologous challenge. These results support the inclusion of broadly neutralizing antibodies in lentivirus control strategies.
摘要
利用马传染性贫血病毒（EIAV）慢病毒模型系统，我们先前证明了广谱中和免疫血浆在严重联合免疫缺陷（SCID）幼马（驹）中的保护作用。然而，在体内选择了一种具有中和抗性的包膜变异体。在这里，我们确定了具有更强广谱中和活性的纯化免疫球蛋白的保护作用。总体而言，保护作用与体外中和活性的广度和效力相关。在 5 只 SCID 驹中，有 4 只完全免受同源性攻击的保护，而在异源性攻击后则发生部分保护。这些结果支持将广谱中和抗体纳入慢病毒控制策略。
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