Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, Verona, Italy.
J Neurophysiol. 2011 Jul;106(1):138-43. doi: 10.1152/jn.00746.2010. Epub 2011 May 4.
The underlying mechanisms of action of transcranial magnetic stimulation (TMS) are still a matter of debate. TMS may impair a subject's performance by increasing neural noise, suppressing the neural signal, or both. Here, we delivered a single pulse of TMS (spTMS) to V5/MT during a motion direction discrimination task while concurrently manipulating the level of noise in the motion stimulus. Our results indicate that spTMS essentially acts by suppressing the strength of the relevant visual signal. We suggest that TMS may induce a pattern of neural activity that complements the ongoing activation elicited by the sensory signal in a manner that partially impoverishes that signal.
经颅磁刺激（TMS）的作用机制仍存在争议。TMS 可能通过增加神经噪声、抑制神经信号或两者兼而有之来降低被试的表现。在此，我们在运动方向判别任务中对 V5/MT 施以单次脉冲 TMS（spTMS），同时操纵运动刺激中的噪声水平。结果表明，spTMS 主要通过抑制相关视觉信号的强度来发挥作用。我们认为 TMS 可能会引发一种神经活动模式，以部分削弱感觉信号的方式补充由感觉信号引发的持续激活。
