Brigham and Women's Hospital, Boston, MA 02115, USA.
Proc Am Thorac Soc. 2011 May;8(2):196-8. doi: 10.1513/pats.201006-041MS.
Human diseases have historically been classified on the basis of their end-organ manifestations, using a traditional clinicopathological approach dating to the 19th century. With the advent of rigorous molecular methodologies at the end of the 20th century, many specific disease determinants were identified and more targeted therapeutic strategies developed. Although the conventional reductionist approach underlying these strategies for understanding disease served us well in the pregenomic era, it hampers our understanding of the complex molecular networks within which disease develops that are increasingly manifest in the current era. This article presents a novel, holistic method for classifying human diseases that can serve as a template for understanding disease pathobiology, prognosis, and treatment.
人类疾病的分类历史上基于其终末器官表现，采用的是传统的临床病理方法，可以追溯到 19 世纪。随着 20 世纪末严格的分子方法的出现，许多特定的疾病决定因素被确定，并开发了更有针对性的治疗策略。尽管这些疾病理解策略所基于的传统还原论方法在基因组前时代对我们很有帮助，但它阻碍了我们对疾病发展中日益显现的复杂分子网络的理解。本文提出了一种新的、整体的人类疾病分类方法，可以作为理解疾病病理生物学、预后和治疗的模板。
